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Barbara B. Book Editor s : Derek J. Chadwick Organizer Search for more papers by this author. Jamie A. Goode Search for more papers by this author.
Series Editor s : Novartis Foundation Search for more papers by this author. Tools Request permission Export citation Add to favorites Track citation. Share Give access Share full text access. It has been shown that oestrogen acts as a neural growth factor with important influences on the survival, plasticity, regeneration and ageing of the mammalian brain. This exciting book brings together leading clinicians and researchers to discuss oestrogen's basic mechanisms of action, the extrahypothalmic brain regions it affects, and its influence on cognitive functions in animals and humans.
Finally, recent research on the role of oestrogens in ageing and dementia, including the significance of oestrogen action in Alzheimer's disease, is discussed.
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The 15 papers contained in this book, together with the extensive discussion sessions that follow them, reveal much new and exciting work in this area, and identify promising new research directions. Page 2. Page 5. Page de titre.
College of Social & Applied Human Sciences (CSAHS)
Mechanism of oestrogen signalling with particular reference to the role of ERb in the central nervous system. Oestrogen receptor function at classical and alternative response elements. General discussion I. Nuclear receptor versus plasma membrane oestrogen receptor. Novel sites and mechanisms of oestrogen action in the brain. Thrombin is made by injured neurons, and signals astrocytes to elicit a protective response. In he was awarded the prestigious William M.
His current research focuses on investigating how the vessels in the brain react after stroke and how tissue reperfusion could be improved. In addition to his work on brain blood flow and cerebrovascular changes, he also uses motor rehabilitation strategies to elucidate how neuronal circuits compensate after stroke. His research focuses on multiparametric imaging of brain structure and function in health and disease, with particular emphasis on i development of tools for improved diagnosis of brain pathophysiology, ii characterization of neural network re organization, and iii monitoring of neuroprotective and -restorative therapies.
He has been particularly involved in preclinical MRI studies to get improved insights in stroke pathophysiology and recovery. Neuroenergetics, or understanding how the brain produces energy to maintain its functions, has attracted much attention recently. From the improvement of cognitive performances through lifestyle changes e. More particularly, studying the cellular links between neuronal activity and energy homeostasis is of utmost importance to elucidate the mechanisms of energy supply dictated by costly neuronal activity. It has also direct impact for neuroprotection.
Andre Obenaus, Ph. His B. Postdoctoral research was completed at the University of California, Los Angeles understanding the anatomical and physiological basis underlying epilepsy. Currently, his research interests include the use of novel magnetic resonance imaging approaches to non-invasively identify the evolution of neuropathology and how the brain responds to therapeutic interventions.
Funded research investigates the influence of vascular alterations in brain trauma, non-invasive and predictive biomarkers relevant to febrile seizures and subsequent development of epilepsy, the evolution of white matter loss in adult and juvenile brain following neurotrauma, and novel therapeutic compounds for mitigating the effects of stroke, among others.
Research into how the brain circuitry is modified by episodes of early life adversity are ongoing as part of the Conte Center UCI. Most recently, Dr. The use of automated computer vision techniques for analysis of biomedical data is a continuing research interest. He has extensive collaborations with national and international researchers to compliment and extend these research endeavors.
Further he has served as a grant reviewer for both national and international funding agencies. He has been invited as a speaker to national and international conferences and has been invited to speak at academic institutions worldwide. My expertise lies at the crossroad of neurobiology and immunology, where I am mainly investigating how we can modulate the immune response to brain injury in order to improve the outcome of stroke.
In particular, my research focuses on the critical role of the gut microbiota as immunomodulators in stroke disease. Commensal gut bacteria have a profound impact on health and diseases. We and others have shown that intestinal microbiota influences stroke pathophysiology by modulating the peripheral immune system Benakis et al.
Nat Med ; Singh et al.
J Neurosci Moreover, the gut microbiota produces several immunoactive metabolites which may impact on recovery from stroke. Benveniste also holds the Charlene A. Jones Endowed Chair in Neuroimmunology. This research continues to date.blacksmithsurgical.com/t3-assets/picture/the-many-hands-of.php
Benveniste has served on the editorial boards of multiple journals including The Journal of Immunology, Journal of Neuroscience, and Journal of Biological Chemistry and is currently on the editorial boards of the Journal of Neuro-Virology and Journal of Neuroinflammation. With 32 years of peer-review panel experience, Benveniste continues as a reviewer for panels such as the Michael J.
Registration Accommodation. Abstracts Abstract Submission Awards. As of June 24, It is subject to change. Presidential Lecture. David Attwell, Ph. University College London, UK The role of capillary pericytes in regulating cerebral blood flow in health, ischaemia and Alzheimer's disease.
Plenary Lecture. Yimin Zou, Ph. Jens P.
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Biography Jens P. Neuron Dreier JP The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. She did her postdoctoral work at the University of Rochester studying the glia-lymphatic glymphatic system, which is a perivascular system for waste removal in the brain. She also studied metabolism in neurons and astrocytes using near-infrared 2-deoxyglucose 2DG-IR imaging.
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I Dr. Lundgaard received a Wallenberg Fellowship and started her own group at Lund University in Sweden, focusing on the glymphatic system. Biography Guohua Xi Dr. Guohua Xi is Richard C. His primary research interests are focused on mechanisms of brain injury after hemorrhagic stroke. Xi has demonstrated that thrombin, complement and iron are involved in brain damage after intracerebral hemorrhage, intraventricular hemorrhage and subarachnoid hemorrhage funded by NIH.
He is also interested in translational stroke research.
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He has found that iron contributes to brain edema formation and neurodegeneration following intracerebral hemorrhage and his translational study was to translate that work to the human. He has more than 25 years of experience with animal models of hemorrhagic stroke. His preclinical work on deferoxamine led to the Phase II clinical trial in intracerebral hemorrhage.
Patrick D. Biography Patrick D. Lyden Dr. Biography Hideo Tsukada Dr. Hideo Tsukada received Ph. He has published more than papers, being awarded by the Society for Nuclear Medicine , and Japan Molecular Imaging Award During my postdoctoral fellowship, I became interested in the metabotropic glutamate receptor subtype 5 mGluR5 , which has been implicated in the pathophysiology of depression in preclinical and clinical studies. As part of this study, we found evidence that [11C]ABP binding may exhibit a diurnal rhythm. This has now been demonstrated in rodent studies.
In particular, I am interested in uncovering the shared role of mGluR5 in circadian dysfunction and depression. In this way, PET can be used as a tool to examine the underlying biology of depression, which could lead to personalized interventions. Professor Baron is a pioneer in the applications of positron emission tomography PET in cerebrovascular diseases, and has used this technique, along with other imaging methods including CT, MR and SPECT, to study the pathophysiology of ischemic stroke and post-stroke recovery.
He discovered, and coined, crossed cerebellar diaschisis and thalamo-cortical diaschisis, and in doing so formally documented the existence of diaschisis. He also documented the dynamics of cortical activation patterns as predictors of motor recovery after subcortical stroke. Recently he has focused on i normobaric hyperoxia as an approach to protect the penumbra until recanalization is achieved; ii post-reperfusion selective neuronal loss, both in animal stroke models and patients; iii early neurological deterioration occurring within 24hrs of intravenous thrombolysis; iv the predictors of early recanalization following intravenous thrombolysis; v PET and MR imaging in cerebral amyloid angiopathy; and vi the first-ever application of functional ultrasdound imaging in rodent stroke models.
He has published around peer-reviewed articles that have been cited over 28, times to date Web of Science h-index: Since , Dr. His research focus at Yale PET Center is on the evaluation and application of in vivo synaptic density imaging in human beings and laboratory animals. He received his Ph. Kazuo Tanishita and worked at University of Pittsburgh Prof. Iwao Kanno. He has published over 60 peer-reviewed papers. He received the Melvin H. Amki received his B.